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Compounds of structure2are prepared by reaction of an arecoline analogue of structure(4with an organometallic compound containing an X-substituted phenyl groupsuch as a compound of structure3STR1Suitably the compound of structure3is a Grignard reagentwhere M is magnesium and Y is a halogen atomor M may be a Group II metal and Y is a halogen atom or a second X-substituted phenyl groupWhen structure3is a Grignard reagentthe reaction is carried out either in a suitable non-ether solventtypically a hydrocarbon or a non-reactive chlorinated hydrocarbonor in a mixture of such a solvent with diethyl etherCompounds of structure2are important intermediates in the preparation of inter alia paroxetine.

Paxil is a brand name of paroxetineapproved by the FDA in the following formulation(s

This medication is not recommended for use during pregnancyIt may harm an unborn babyand babies born to mothers who have used it during the last 3 months of pregnancy may sometimes develop withdrawal symptoms such as feeding/breathing difficultiesseizuresmuscle stiffnessor constant cryingHoweversince untreated mental/mood problemssuch as depressionpanic attackobsessive-compulsive disorderand anxietycan harm a pregnant woman and her unborn babydo not stop taking this medication unless directed by your doctorInsteadask your doctor if a different medication would be right for youIf you are planning pregnancybecome pregnantor think you may be pregnanttell your doctor right away.

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